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Effect of recombinant PEDF on apoptosis of HUVEC. The addition of VEGF protected HUVEC from apoptosis induced by low serum. Apoptosis of HUVEC was significantly increased by the addition of rPEDF or bevacizumab (∗∗∗∗ p < 0.0001; one-way ANOVA with Dunnett's multiple comparison test; VEGF/ECG medium versus VEGF/ECG medium + rPEDF and bevacizumab). Data are presented as mean ± SD of the average apoptotic cell number from at least 6 micrographs.
