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. 2015 Dec 1;2015:863845. doi: 10.1155/2015/863845

Figure 7.

Figure 7

Effects of subretinal transplantation of RPE cells transfected with the PEDF gene on laser-induced CNV in a rat model. (a) Fluorescein angiograms of rat eyes 1 and 2 weeks after laser injury and cell transplantation showed the decrease in leakage in eyes transplanted with transfected RPE cells secreting 2 ng rPEDF/day, but not in eyes transplanted with Venus-expressing cells or sham-operated eyes. (b) Distribution of total CNV lesions, classified by a blinded observer into grade 0 (no leakage), grade 1 (very mild leakage), and grade 2 (clear leakage), showed that the eyes transplanted with PEDF-transfected cells had fewer grade 2 lesions than the other groups. Each group comprised at least 6 animals. (c) Quantification of clinically relevant grade 2 CNV lesions in rat eyes after 1 and 2 weeks showed that eyes transplanted with rPEDF-expressing cells had significantly fewer grade 2 lesions (1 week: ∗ p = 0.042; 2 weeks: ∗∗ p = 0.0023). (d) Exemplary fluorescein angiograms of grades 0, 1, and 2 lesions.