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. 2015 Dec 1;2015:863845. doi: 10.1155/2015/863845

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Copyright © 2015 Sandra Johnen et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Choroidal flat-mounts of retinas from a rat model of laser-induced CNV. (a) Exemplary fluorescence micrographs of isolectin B4 (vascular leakage) stained choroidal flat-mounts 2 weeks after laser treatment. Note the decrease in B4 staining in the retinas transplanted with RPE cells transfected with the PEDF gene secreting 2 ng rPEDF/day. (b) Quantitative analysis of area of vascular leakage 2 weeks after laser injury showed that transplantation of PEDF-transfected RPE cells reduced the area of leakage by over 50% compared to control, sham-operated eyes, and eyes transplanted with Venus-expressing cells (^∗∗ p = 0.0012, rPEDF versus no injection, sham injection, and Venus-expressing cells). (c) Choroidal flat-mounts of rat eyes 8 weeks after laser injury showed that the reduction in leakage observed at 2 weeks in eyes transplanted with PEDF-transfected RPE cells was still approximately 50% of the leakage in eyes transplanted with Venus-expressing cells (^∗∗ p = 0.0022).