Table 1.
Cytokines and chemokines in bronchoalveolar lavage fluid in 1-hit VILI
| C WT | C KO | LV T WT | LV T KO | HV T WT | HV T KO | |
|---|---|---|---|---|---|---|
| IL-6 [ng/ml] | B.D. | B.D. | 104.0 (17.0) | 101.0 (12.4) | 156.1 (15.9)*** | 142.7 (18.6) |
| KC [ng/ml] | 51.4 (0.7) | B.D. | 336.7 (70.0)** | 463.4 (123.7) | 423.4 (94.0)** | 505.9 (59.3) |
| MIP-2 [ng/ml] | B.D. | B.D. | 239.6 (56.5)* | 233.2 (35.4) | 189.2 (18.4) | 216.2 (20.6) |
| IL-1β [ng/ml] | B.D. | B.D. | 69.9 (21.9)* | 64.9 (15.9) | 57.3 (14.5)* | 66.0 (21.3) |
Cytokines and chemokines [pg/ml] in bronchoalveolar lavage fluid of wild-type (WT) and RAGE knockout (KO) mice with healthy lungs ventilated for 5 h with low tidal volumes (LVT ~ 7.5 ml/kg) or high tidal volumes (HVT ~ 15 ml/kg). Non-ventilated mice (C) served as control. Data represent mean (SEM) of n = 6 to 9 mice/group. *p < 0.05; **p < 0.01; ***p < 0.001 vs controls. B.D., below detection.