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. 2015 Sep 16;88(6):1427–1433. doi: 10.1038/ki.2015.270

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Copyright © 2015 International Society of Nephrology

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Study design. *A sequential testing procedure was used to determine the earliest time point at which the change from baseline in serum potassium was significant. Starting at 48 h, each time point was tested in order of reverse chronology (i.e., 48, 44, 41, 38 h, etc.), with the preceding time point assessed only if the change from baseline in serum potassium for the previously examined time point was statistically significantly. ^†Patients with serum potassium 5.5 to <6.5 mEq/l after the 3-day low-potassium, low-sodium diet run-in entered the treatment phase. BID, twice daily; CRU, clinical research unit; K⁺, potassium; Na⁺, sodium.