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. 2015 Aug 26;88(6):1419–1426. doi: 10.1038/ki.2015.247

Figure 2.

Figure 2

Effect of insulin at 0.01 and 0.035 mU/kg per min on forearm muscle net protein balance. (a, b) In control subjects, the negative net protein balance observed in the basal, postabsorptive state was markedly decreased by insulin at both 0.01 (n=5) and 0.035 mU/kg per min (n=7). (a) Contrariwise, no effect of low-dose (0.01 mU/kg per min) insulin infusion was observed in patients with chronic kidney disease (CKD) (n=5). (b) At higher insulin infusion rates (0.035 mU/kg per min) net protein balance declined in patients (n=7) similarly to control subjects. Values are mean±s.e.m. aStatistically significant differences (P⩽0.01 or less) between basal and insulin-infused periods. bStatistically significant differences (P⩽0.03 or less) between patients with CKD and controls.