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. 2015 Dec 15;9:456. doi: 10.3389/fnins.2015.00456

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Copyright © 2015 Guizard, Nakamura, Coupé, Fonov, Arnold and Collins.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lesion simulation examples with the original image, MS lesion simulation and the different lesion filling results LWM, FSL, LEAP, and NLM for three different lesion sizes [(A) = large, (B) = medium and (C) = small]. The red arrows point to anatomically improbable lesion filling results, the yellow arrows point to intensity problems while the green arrows point to plausible and realistic anatomy. The original lesion boundary and the red square on the axial image depicts the zoom-in image region shown below it. Note that these images were generated at β0.