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. Author manuscript; available in PMC: 2015 Dec 15.
Published in final edited form as: Cell Physiol Biochem. 2015 Aug 28;37(2):432–444. doi: 10.1159/000430366

Fig. 7.

Fig. 7

cADPR or NAADP-sensitive Ca2+ regulates O2−. Production. CAMs were pretreated with 8-Br-cADPR (30 μM) or NED-19 (10 μM) and then stimulated with 7-Ket for 24 hours. Representative Ca2+ traces (A) and summarized data (B) showing the level of cytosolic Ca2+ in CAMs. (C) Summarized ESR data showing the relative O2−. production in CAMs before and after treatment with 8-Br-cADPR or NED-19. (D) Typical representative fluorescent images showing nuclear translocation of Nrf2 in CAMs pretreated with 8-Br-cADPR or NED-19. (E) Summarized data showing nuclear Nrf2 activity in CAMs pretreated with 8-Br-cADPR or NED-19. *P<0.05, vs. control; #P<0.05, vs. CAMs treated with 7-Ket (n=6).