Figure 1.
Transcript Atlases Reveal a High Degree of Territoriality of Gene Expression in the Arterial Wall
(A) Anatomy of WT and Apoe−/− aortas and RLNs (left) and the numbers of differentially expressed mRNAs in two-tissue comparisons (right) are shown of 78- to 85-week-old mice. Student’s t test with Benjamini-Hochberg correction; n = 3 WT and Apoe−/− mice except n = 4 for Apoe−/− adventitia no plaque and n = 4 for ATLOs.
(B) Adventitia cluster show total differentially expressed genes (left) and mRNAs in respective GO terms (right).
(C) Plaque-ATLO cluster is shown in respective GO terms (right). Cluster analyses were performed using ANOVA with Benjamini-Hochberg correction. Signal intensities and statistics are reported in Table S1 (see also Figure S3).