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Resistance mutations. Mutations identified in EV71/CVA16 after passage in the presence of NLD, GPP3, ALD or a combination of NLD/GPP3 (see Fig. 1). CVA16 isolates resistant to NLD or ALD were not selected.
| Virus/Compound | Mutation(s) | Number sequenced |
|---|---|---|
| EV71/NLD | I113M (62%), I113L (31%), I113M/V123I (7%) | n = 13 |
| EV71/GPP3 | I113M/V123I | n = 4 |
| EV71/ALD | I113M/V123I | n = 1 |
| EV71/NLD + GPP3 | I113M/V123I | n = 12 |
| CVA16/GPP3 | L113F | n = 10 |
