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. 2015 Dec 15;5:18093. doi: 10.1038/srep18093

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By transfecting the PCMV5-HA-PP4 expression vector into HepG2 cells, we obtained several clonal cell lines (a). PP4 over-expression resulted in reduced glycogen levels (b) and impaired activation of the AKT/GSK3β pathway (c). Similar results were obtained from AD-mediated PP4 over-expression in mouse primary hepatocytes (d). Data represent means ± S.D. (n = 3 independent experiments). ^#P < 0.05 and ^##P < 0.01; the 2 groups are as indicated by the line. T, TNF-α; Con, control; Con AD, control AD.