Figure 5.
Inference of Gene-Conversion-Corrected Mutation Rate in Simulated Data
We simulated a chromosome of 50 cM for 250 diploid samples by using μ = 2 × 10−8 for the mutation rate and a probability of 6 × 10−6 for a base pair to be involved in a non-crossover gene-conversion event. We matched the allele-frequency spectrum of the simulated samples to the spectrum found in real data for IBD-segment detection with GERMLINE. We used several values of the GERMLINE allowed mismatching sites (“-het”) to assess the impact of this parameter in the results. Negligible biases were observed for the recovered mutation rate. Error bars represent SE.