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. Author manuscript; available in PMC: 2015 Dec 15.
Published in final edited form as: Medchemcomm. 2014 Dec 1;5(12):1879–1886. doi: 10.1039/C4MD00291A

Scheme 1.

Scheme 1

Synthesis of compound 14a. Reagents and conditions: (a) TMSCCH, CuI, Pd(PPh3)4, Et3N, THF, 85%; (b) azidomethyl pivalate, TBAF, CuSO4·5H2O, (+)-sodium l-ascorbate, DMF, H2O, 65 °C, 53%; (c) NaOH, H2O, MeOH, 61%.