Skip to main content
. Author manuscript; available in PMC: 2015 Dec 15.
Published in final edited form as: Medchemcomm. 2014 Dec 1;5(12):1879–1886. doi: 10.1039/C4MD00291A

Scheme 2.

Scheme 2

Synthesis of N-substituted triazoles. Reagents and conditions: (a) TBAF, BnN3, DIPEA, CuI, MeOH, 69%; (b) TBAF, RI, NaN3, CuSO4·5H2O, (+)-sodium l-ascorbate, DMF, H2O, 65 °C, 20–77%; (c) (i) KOTMS, MeCN, 81%; (ii) MeI, NaN3, CuSO4·5H2O, (+)-sodium l-ascorbate, DMF, H2O, 65 °C, 24%; (d) KOTMS, MeCN, 59–100%; (e) (i) TBAF, RN3, DIPEA, CuI, MeOH; (ii) KOTMS, MeCN, 14–50%.