Scheme 4.
Synthesis of azetidine, pyrrolidine and 3-piperidine derivatives. Reagents and conditions: (a) MsCl, Et3N, DCM; (b) NaN3, DMF, 60 °C; (c) 12, TBAF, DIPEA, CuI, MeOH; (d) TFA, DCM; (e) RCOCl, Et3N, DCM; (f) LiOH (aq), MeOH.
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