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Inhibitory effect of the two enantiomers of 28n in seven JmjC KDMs
| pIC50a KDM |
|||||||
|---|---|---|---|---|---|---|---|
| Compound | 2A | 3A | 4A | 4C | 4E | 5C | 6B |
| 35 | 7.2 ± 0.16 (4) | <4.0 (4) | 4.8 ± 0.28 (2) | 4.8 ± 0.10 (4) | <4.0 (2) | 5.7 ± 0.07 (2) | <4.0 (4) |
| 36 | 5.5 ± 0.09 (2) | ND | ND | <4.0 (6) | <4.0 (6) | ND | 4.5 ± 0.24 (2) |
Mean pIC50 ± standard error of the mean (number of determinations) as determined by AlphaScreen.
