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. Author manuscript; available in PMC: 2015 Dec 15.
Published in final edited form as: Chem Sci. 2014 May 1;5(5):1765–1771. doi: 10.1039/C4SC00020J

Figure 1. Identification of selective inhibitors of carnitine biosynthesis.

Figure 1

AR692B inhibits BBOX – the final enzyme of carnitine biosynthesis and an Fe(II)/ 2-oxoglutarate dependent oxygenase(A). A ‘fluoride release’ assay (B) enables efficient screening of potential inhibitors (C) and the identification of AR692B as a potent BBOX inhibitor. Structure–activity relationship results (D, E) imply that the pyridine nitrogen, the C-3 phenolic hydroxyl, hydrophobic side chain and carboxylate contribute to inhibition.