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. 2015 Dec 15;15:117. doi: 10.1186/s12935-015-0267-0

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© Matsuzaki et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Mechanisms of platinum resistance in CCC. At present, five mechanisms of platinum resistance have been characterized in CCC, including pre-, on-, post-, and off-target mechanisms, and slow cell proliferation. ABCC3 ATP-binding cassette, subfamily C, member 3, ERCC1 excision repair cross-complementing rodent repair deficiency complementation group 1, EGFR epidermal growth factor receptor, HER2 human epidermal growth factor receptor 2