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. 2015 Dec 15;9:93. doi: 10.1186/s12918-015-0238-z

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© Marmiesse et al. 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Simulations of Escherichia coli growing with different combinations of lactose and D-glucose. Simulations were performed using the genome-scale metabolic model of E. coli K-12 MG1655 [37] and the reconstructed regulatory network of the lac operon. Are shown here the initial concentrations of the two carbon sources, the calculated steady-state (attractor of size one) qualitative value for some of the components of the regulatory network, and the value of the objective function (growth rate). Lower graph legend : FBA: Simulation performed using FBA without considering the regulatory network; RSA + FBA: Simulation performed using RSA and FBA; experimental data: values extracted from [36]. Regulatory network legend: E: EIIA component of the D-glucose PTS transporter; P: lactose permease; B: Beta-galactosidase; I: lac I regulator