Table 1.
Amino acid sequences of CAR domains. The ten n-terminal and ten c-terminal amino acids which flank the protein regions utilized as CAR domains (with the exception of c-myc for which the sequence is listed in its entirety)
| Murine CAR sequences: | ||
| Domain | N-terminus | C-terminus |
| c-myc tag | EQKLISEEDL | |
| CD8 hinge | VISNSVMYFS | SVKGTGLDFA |
| CD28 transmembrane and cytoplasmic | ALVVVAGVLF | PARDFAAYRP |
| CD3ζ cytoplasmic | LRAKFSRSAE | ALHMQTLAPR |
| Human CAR sequences: | ||
| Domain | N-terminus | C-terminus |
| CD8 hinge | SALSNSIMYF | GGAVHTRGLD |
| CD28 transmembrane and cytoplasmic | FWVLVVVGGV | PPRDFAAYRS |
| CD3ζ cytoplasmic | RVKFSRSADA | ALHMQALPPR |