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. 2015 Dec 15;14:209. doi: 10.1186/s12943-015-0478-y

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© French et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Proposed Model of TRAIL-Susceptiblity in Breast Tumour Subpopulations: (a) Epithelial-like cells have cytoplasmic cFLIP and consequently are resistant to TRAIL-mediated apoptosis. (b) Mesenchymal-like cells have comparatively reduced cytoplasmic cFLIP and elevated nuclear cFLIP due to its role in the relatively more active Wnt pathway, and are consequently TRAIL sensitive (c) The consequences of cFLIP inhibition: sensitisation to TRAIL, reduction in Wnt signalling and potentially a reduction in bCSC self-renewal and proliferation