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. 2015 Dec 14;8:41. doi: 10.1186/s13040-015-0074-0

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© De et al. 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Functional relationship networks generated from Integrated Multi-Species Prediction (IMP) from identified SNP- SNP interactions that are highly associated with BMI. Identified SNPs were mapped to their respective genes. Gene pairs were used to query IMP to make functional connections between them. IMP is a web-based tool that mines empirical data to provide a predictive probability that two genes have a functional relationship. Nodes in the network represent genes. Query genes are represented with larger nodes. Edges between nodes represent a functional relationship between two genes. Shown are interactions between (a) rs749457 in ASTL and rs1799998 in CYP11B2 (b) rs3102976 in EZR and rs997295 in MAP2K5 (c) rs2268484 in CAV3 and rs8038415 in IGF1R