Figure 1A.

ANS Board Game Section, Ganglionic Synapse.

A close-up of the preganglionic cholinergic nerve terminal and postganglionic cell body from the board game (labeled “1A” in Figure 1). Because all ANS pregangionic nerves are cholinergic, the figure is included in the top half of the cranial, thoracic, lumbar and sacral pathways. The synapse was drawn to include grey circles containing the neurotransmission components of the pathways and black squares containing the end product or result of the actions of the components that are in grey circles. For example, the first black square is labeled ACh for acetylcholine. To make ACh, the choline hemitransporter (grey circle labeled CHT) must taken up choline (another grey circle). Choline-acetytransferase (grey circle labeled ChAT) combines choline with acetylCoA (another grey circle) to make ACh, which is in the black square, indicating the end of the reaction and the location to which the player will move next in the game once all the component cards for that reaction have been collected. CHT, choline hemitransporter; ChAt, choline acetyltransferase; ACh, acetylcholine; VAT, vesicle-associated transporter; Ca⁺⁺, calcium ions; VAMPs, vesicle-associated membrane proteins; SNAPs, synaptosomal nerve-associated proteins; Na⁺⁺, sodium ions.