Pattern of serum-induced proliferation |
Increased in a time-dependent manner |
Same pattern as HK-2 cells |
Same pattern as HK-2 cells |
Effect of PDTC on proliferation |
Reduced at 4-24 h |
Reduced at 8-24 h |
Reduced at 24 h |
Endogenous NF-κB reporter activity |
High |
Moderate |
Low |
Effect of exogenous LPS on NF-κB reporter activity |
Increased |
No change |
No change |
Effect of exogenous TNF-α on NF-κB reporter activity |
Increased |
Increased |
Increased |
Effect of PDTC on TNF-α-induced NF-κB reporter activity |
Reduced |
No change |
No change |
Effect of PDTC on TNF-α-induced nuclear NF-κB protein levels |
Reduced p50 |
Reduced p50 |
Reduced p50 |
Effect of exogenous LPS and TNF-α on proliferation at 4 h and 24 h |
Same as unstimulated cells |
Same as unstimulated cells |
Same as unstimulated cells |