Figure 3.

Positions of the Early GMNN Mutations and Destruction Signal in Geminin

The early de novo mutations could lead to elimination of the destruction signal (boxed) with use of Met28 as an alternative initiation codon. Affected amino acids are represented in red; start codon (Met1), the proposed alternative start codon (Met28), and residues Met4 and Met89 are represented in green. The amino acids encoded by exon 2 and exon 3 of GMNN are in separate brackets with exon numbers labeled above.