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. 2015 Nov 17;43(22):10623–10632. doi: 10.1093/nar/gkv1200

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Time resolved siRNA-mediated target knockdown with respect to initial siRNA concentration at three different levels of basal target mRNA. In all six plots, target concentration (in percent of basal target level) is plotted against reaction time (in h) and logarithmically-scaled initial siRNA concentration (in copies/cell). Simulation results of the dissociative model in the first column are presented in parallel with the ones of the associative model in the second column. Row-wise, absolute basal target levels increase by 10-fold from 10 to 100 to 1000 copies/cell.