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. 2015 Sep 3;43(22):10689–10699. doi: 10.1093/nar/gkv867

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — DNA methylation level changes of the PEG3 and H19/IGF2 domains. A set of human DNA derived from two normal (brain and liver) and six cancer tissues (breast, lung, kidney, colon, ovary and liver) were used to survey the DNA methylation levels of the PEG3 domain (A) and the H19/IGF2 domain (B). Three genomic regions for each domain were targeted and analyzed with COBRA as shown in the upper panel. The bottom panel shows the genomic structures of two imprinted domains along with their DNA methylation changes observed in cancers.