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. 2015 Sep 17;43(22):10760–10781. doi: 10.1093/nar/gkv934

Figure 1.

Figure 1.

Silencing of CITED2 downregulates ERCC1 expression and cell viability to cisplatin. (A) mRNA levels of the repair gene ERCC1 are reduced in HEK293 cells following CITED2 silencing using shRNA. (B and C) Protein levels of the repair gene ERCC1 are reduced in HEK293 cells following CITED2 silencing. (D) Sensitization of HEK293 cells to cisplatin by shCITED2 compared to shControl. (E) Apoptotic sub-G1 cells in response to cisplatin. The experiments shown in this study were performed in triplicate. Mock control which has no exogenous shRNA was also included for comparison in (A–D).