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. 2015 Dec 15;5:18138. doi: 10.1038/srep18138

Table 2. Results of linear regression between bone metabolism marker and 25(OH) D in different sets of adjustment.

	All			low calcium (<median)			high calcium (≥median)
	effect^a	(CI)	p	effect^a	(CI)	p	effect^a	(CI)	p
Basic model^b
OC	0.01	(−0.07, 0.08)	0.896	−0.02	(−0.12, 0.10)	0.765	−0.06	(−0.16, 0.04)	0.268
β-CTx	−10.2	(−14.4, –6.1)	<0.001	−14.4	(−20.6, −8.1)	<0.001	−9.0	(−14.7, −3.4)	0.002
β-CTx to OC ratio	−1.7%	(−2.2, −1.1)	<0.001	−2.2%	(−3.1, −1.4)	<0.001	−1.0%	(−1.7, −0.4)	0.003
Extended model^c
OC	0.01	(−0.07, 0.09)	0.795	−0.01	(−0.13, 0.11)	0.872	−0.05	(−0.15, 0.05)	0.343
β-CTx	−10.5	(−14.9, –6.2)	<0.001	−15.3	(−21.8, –8.8)	<0.001	−8.9	(−14. 8, −3.0)	0.003
β-CTx to OC ratio	−1.7%	(−2.3, –1.2)	<0.001	−2.3%	(−3.2, −1.4)	<0.001	−1.1%	(−1.8, −0.4)	0.002
Full model^d
OC	0.03	(−0.06, 0.11)	0.504	0.01	(−0.12, 0.14)	0.899	−0.03	(−0.14, 0.09)	0.636
β-CTx	−9.6	(−14.3, −45.0)	<0.001	−14.7	(−21.6, –7.7)	<0.001	−7.8	(−14.2, –1.4)	0.018
β-CTx to OC ratio	−2.4%	(−2.4, −1.2)	<0.001	−2.4%	(−3.4, –1.5)	<0.001	−1.2%	(−2.0, –0.4)	0.003

^aeffect: beta for OC and β-CTx, %change for β-CTx to OC ratio.

^bBasic model: adjusted for city, study, sex, fasting status, time of blood drawn.

^cExtended model: basic model adjustment plus BMI, BMI², growth rate, detectable testosterone/estradiol.

^dFull model: extended model adjustment plus maternal and paternal education and physical activity.