TABLE 1.

Up-regulated genes of oxidative stress/antioxidant defense pathways in Nrf2 KO heart

Gene Symbol	Fold Change	Function	Oxidative Stress Pathway
Scd1	8.1	Stearoyl-CoA desturase-1; fatty acid and cholesterol metabolism, insulin resistance, oxidative stress	Superoxide production
Txnip	4.2	Thioredoxin-interacting protein; energy metabolism, ROS metabolism, insulin resistance, β-cell function	Inhibiting reduced thioredoxin
Ccs	2.6	Copper chaperone for superoxide dismutase; controls copper incorporation into SOD1	Copper chaperone for SOD1
Hbq1	2.5	Hemoglobin subunit theta 1; early erythroid function	Oxygen transport
Noxa1	2.3	NADPH oxidase activator 1; regulates superoxide anion production and redox signaling through NOX	NOX activator
Vim	1.9	Vimentin; cell attachment, migration, and signaling	Oxygen transport

NOX, NADPH oxidase.