TABLE 2.
Down-regulated genes of oxidative stress/antioxidant defense pathways in Nrf2 KO heart
| Gene Symbol | Fold Change | Function | Oxidative Stress Pathway |
|---|---|---|---|
| Mpp4 | 4.9 | Membrane palmitoylated protein 4; calcium homeostasis, ROS production, photoreceptor signaling | Oxidative stress responsive gene |
| Ift172 | 3.0 | Intraflagellar transport 172; intraflagellar transporter, oxygen transporter | Oxygen transport |
| Rag2 | 3.0 | Recombination activating gene 2; immune, inflammation, ROS response | Peroxidase function |
| IL22 | 2.6 | Interleukin 22; inflammation, ROS production, natural killer and T-cell functions | Regulates ROS metabolism |
| Lpo | 2.5 | Lactoperoxidase; innate immune function, bacterial killing | Peroxidase function |
| Recql4 | 2.4 | ATP-dependent DNA helicase Q4; skeleton and skin development, ROS production | Superoxide metabolism |
| Gpx8 | 2.3 | Glutathione peroxidase 8; peroxide metabolism, antioxidant function | Glutathione peroxidase |
| Srxn1 | 2.1 | Sulfiredoxin 1; reduction of peroxiredoxin-sulfinic acid (Prx-SO2H) to sulfenic acid (Prx-SOH) | Reduce Prx for peroxide metabolism |
| Ngb | 2.1 | Neuroglobin; protection against hypoxia and ROS injuries | Oxygen transport |
| Noxo1 | 2.0 | NADPH oxidase organizer 1; regulates superoxide production | Regulates NOX to produce superoxide |
| Prnp | 2.0 | Major prion protein; prion protein, glucose uptake, transport of Cu2+ | Oxidative stress responsive gene |
| Gpx2 | 2.0 | Glutathione peroxidase 2; detoxification of hydrogen peroxide | Glutathione peroxidase |
| Gpx6 | 1.9 | Glutathione peroxidase 6; detoxification of hydrogen peroxide | Glutathione peroxidase |
| Ercc2 | 1.9 | Excision repair cross-complementing rodent repair deficiency, complementation group 2; transcription-coupled excision repair | Oxidative stress responsive gene |
| Ptgs2 | 1.8 | Prostaglandin-endoperoxide synthase 2; prostaglandin biosynthesis | Prostaglandin metabolism |
| Mpo | 1.8 | Myeloperoxidase; inflammation, innate immune function, oxidant production | Myeloperoxidase function |
| Nqo1 | 1.8 | NAD(P)H:quinone oxidoreductase 1 | Two electron reduction of quinones |
| Cygb | 1.8 | Cytoglobin; oxygen transport, scavenging NO and ROS | Oxygen transport, antioxidant |
NOX, NADPH oxidase; NO, nitric oxide.