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. 2015 Dec 15;5:18241. doi: 10.1038/srep18241

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Copyright © 2015, Macmillan Publishers Limited

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There was a significant difference in the serum concentration of metabolites belonging to a number of classes when samples from C57BL/6 J and COMT^−/− mice were compared. The metabolites which were significantly altered included acylcarnitines such as (A) C2 (acetylcarnitine) and (B) C5 (valerylcarnitine), glycerophospholipids such as (C) PC aa C34:2 (phosphatidylcholine diacyl C34:2), and (D) the bioamine kynurenine. These differences were not significant for the majority of metabolites when samples from C57BL/6 J mice and COMT^−/− mice treated with Sildenafil citrate were compared. n = 10–23, Kruskal-Wallis test; *p < 0.05, **p < 0.01. ‘Sc’ indicates mice were treated with Sildenafil citrate.