Table 2. Prevalence of FEN1 genotype frequencies and gallbladder cancer risk by gallbladder stone.
| FEN1 genotype | Controls n(%) | Cases n(%) | Crude OR 95% CI) | Adjusted ORa (95% CI) | Trend test (P value)b | |
|---|---|---|---|---|---|---|
| Total | C.-69G > A | |||||
| AA | 70 (20.6) | 38 (11.1)c | 1.0 (reference) | 1.0 (reference) | P < 0.001 | |
| GA | 160 (47.2) | 164 (48.1) | 1.73 (1.02–2.63) | 1.74 (1.02–2.64) | ||
| GG | 109 (32.2) | 139 (40.8) | 2.29 (1.31–3.95) | 2.31 (1.32–3.96) | ||
| Sex | ||||||
| Male | AA | 22 (20.8) | 12 (11.1) | 1.0 (reference) | 1.0 (reference) | P < 0.001 |
| GA | 50 (47.2) | 51 (47.3) | 1.75 (1.03–2.65) | 1.76 (1.04–2.66) | ||
| GG | 34 (32.0) | 45 (42.6) | 2.42 (1.32–4.96) | 2.43 (1.35–4.98) | ||
| Female | AA | 48 (20.6) | 26 (11.2) | 1.0 (reference) | 1.0 (reference) | P < 0.004 |
| GA | 110 (47.2) | 113 (48.5) | 1.63 (1.01–2.58) | 1.64 (1.02–2.59) | ||
| GG | 75 (32.2) | 94 (40.3) | 2.18 (1.29–3.37) | 2.19 (1.30–3.38) | ||
| Gallstone status | ||||||
| Absence | AA | 67 (21.1) | 30 (20.8) | 1.0 (reference) | 1.0 (reference) | P = 0.81 |
| GA | 145 (45.6) | 66 (45.8) | 1.1 (0.3–3.0) | 1.1 (0.3–3.1) | ||
| GG | 106 (33.3) | 48 (33.3) | 1.2 (0.4–3.2) | 1.3 (0.4–3.3) | ||
| Presence | AA | 3 (14.3) | 8 (4.1) | 1.0 (reference) | 1.0 (reference) | P < 0.001 |
| GA | 15 (71.4) | 98 (49.7) | 2.2 (1.4–3.4) | 2.3(1.5–3.5) | ||
| GG | 3 (14.3) | 91 (46.2) | 5.9 (1.8–18.6) | 6.8 (2.1–28.3) | ||
| Size of largest gallstone | ||||||
| <2 cm | AA | 3 (33.3) | 3 (3.6) | 1.0 (reference) | 1.0 (reference) | P < 0.001 |
| GA | 6 (66.7) | 57 (68.7) | 1.9 (0.7–3.8) | 2.0 (0.7–3.9) | ||
| GG | 0 (0) | 23 (27.7) | 3.4 (1.6–16.2) | 3.5 (1.7–17.2) | ||
| ≥2 cm | AA | 0 (0) | 5 (4.4) | 1.0 (reference) | 1.0 (reference) | P < 0.001 |
| GA | 9 (75.0) | 41 (36.0) | 2.0 (0.9–4.2) | 2.1 (1.0–4.5) | ||
| GG | 3 (25.0) | 68 (59.6) | 7.2 (1.7–18.6) | 7.3 (1.8–18.8) | ||
| Total | C.4150G > T | |||||
| TT | 74 (21.8) | 44 (12.9)d | 1.0 (reference) | 1.0 (reference) | P < 0.001 | |
| GT | 167 (49.3) | 166 (48.4) | 1.93 (1.04–2.91) | 1.95 (1.09–2.94) | ||
| GG | 98 (28.9) | 131 (38.7) | 2.56 (1.37–5.39) | 2.57 (1.39–5.52) | ||
| Sex | ||||||
| Male | TT | 23 (21.7) | 14 (13.0) | 1.0 (reference) | 1.0 (reference) | P < 0.001 |
| GT | 52 (49.1) | 52 (48.1) | 1.59 (1.01–2.32) | 1.60 (1.02–2.33) | ||
| GG | 31 (29.2) | 42 (38.9) | 2.43 (1.31–3.42) | 2.44 (1.32–3.43) | ||
| Female | TT | 51 (21.9) | 30 (12.5) | 1.0 (reference) | 1.0 (reference) | χ2 < 0.001 |
| GT | 114 (48.9) | 114 (48.9) | 1.71 (1.01–2.62) | 1.72 (1.02–2.63) | ||
| GG | 68 (29.2) | 89 (38.6) | 2.16 (1.22–4.91) | 2.17 (1.23–4.92) | ||
| Gallstone status | ||||||
| Absence | TT | 69 (21.8) | 29 (20.1) | 1.0 (reference) | 1.0 (reference) | P = 0.89 |
| GT | 152 (47.8) | 68 (47.2) | 1.2 (0.4–3.1) | 1.3 (0.5–3.2) | ||
| GG | 97 (30.4) | 47 (32.6) | 1.3 (0.5–3.8) | 1.4 (0.6–3.9) | ||
| Presence | TT | 3 (14.3) | 15 (7.6) | 1.0 (reference) | 1.0 (reference) | P < 0.001 |
| GT | 15 (71.4) | 98 (49.7) | 3.6 (1.4–9.6) | 3.7 (1.4–9.8) | ||
| GG | 3 (14.3) | 84 (42.6) | 7.1 (2.1–20.1) | 7.2 (2.2–20.2) | ||
| Size of largest gallstone | ||||||
| <2 cm | TT | 3 (33.3) | 3 (3.6) | 1.0 (reference) | 1.0 (reference) | P < 0.001 |
| GT | 6 (66.7) | 55 (66.3) | 2.1 (0.8–4.2) | 2.2 (0.8–4.3) | ||
| GG | 0 (0) | 25 (30.1 | 5.4 (1.2–16.6) | 5.5 (1.3–16.7) | ||
| ≥2 cm | TT | 0 (0) | 12 (10.5) | 1.0 (reference) | 1.0 (reference) | P < 0.001 |
| GT | 9 (75.0) | 43 (37.7) | 2.2 (0.9–4.8) | 2.3 (1.0–4.9) | ||
| GG | 3 (25.0) | 59 (51.8) | 8.1 (1.4–19.4) | 8.2 (1.5–19.8) | ||
aAdjusted for age, sex and gallstone.
bTrend test assessing correlation between gallbladder cancer risk and predicting high risk FEN1 genotypes.
cNumbers in parenthesis refer to percentages.
dNumbers in parenthesis refer to percentages.