Table 3. Association of genotypic data with clinicopathological features of gallbladder carcinoma patients.

Variable (# of cases)	C.69G > A						C.4150G > T
	AA	GA	GA	Crude OR (95%)	Adjust OR (95% CI)a	Trend test (P value)b	TT	GT	GG	Crude OR (95%)	Adjust OR (95% CI)a	Trend test (P value)b
Sex						P = 0.83						P = 0.97
Male	12	51	45	1.0 (reference)	1.0 (reference)		14	52	42	1.0 (reference)	1.0 (reference)
Female	26	113	94	1.1 (0.2–2.1)	1.1 (0.3–2.2)		30	114	89	1.05 (0.1–1.1)	1.06 (0.2–1.2)
Pathology grade						P = 1.0						P = 1.0
G1 (54)	6	25	23				7	27	20
G2 (81)	9	37	35				10	39	32
G3 (162)	18	81	63				21	81	60
G4 (44)	5	21	18				6	18	20
TNM stage						P = 1.0						P = 1.0
I (31)	4	15	12				3	15	13
II (45)	5	24	16				6	25	14
III (44)	5	21	18				5	20	19
IV (86)	9	40	37				10	41	35
V (135)	15	64	56				20	64	51
Tumor differentiation						P = 1.0						P = 1.0
Well (47)	6	25	16				6	25	16
Moderate (123)	13	58	52				15	59	49
Poor (144)	16	70	58				17	69	58
Undifferentiated (27)	3	11	13				6	12	9
Lymph node metastasis						P = 1.0						P = 1.0
+(202)	22	95	85				25	97	80
−(139)	16	69	54				19	68	52
Distant metastasis						P = 1.0						P = 1.0
+(108)	12	52	44				14	54	40
−(233)	26	112	95				30	111	92
Tumor size						P = 1.0						P = 1.0
<2 cm (146)	17	74	55				20	70	56
≥2 cm (195)	21	90	84				24	95	76

^aAdjusted for age, sex, pathology grade , TNM stage , tumor differentiation , lymph node metastasis , distant metastasis , tumor size.

^bTrend test assessing correlation between gallbladder cancer risk and predicting high risk FEN1 genotypes.