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. 2015 Nov 23;112(49):E6780–E6789. doi: 10.1073/pnas.1512968112

Fig. 4.

Fig. 4.

Muscle-specific KLF15 overexpression ameliorates DMD phenotype in mdx mice. (A) qRT-PCR of Klf15 in quadriceps from mice of indicated genotypes (n = 5). (B) GSEA demonstrating that genes reduced in mdx skeletal muscle tissue (curated from ref. 44) are highly enriched for those induced by the muscle-specific KLF15 transgene. (C) Treadmill exercise capacity (n = 9 MTg mdx, n = 5 non-Tg mdx) and (D) wire-hang test (n = 9 MTg mdx, n = 15 non-Tg mdx) in mice of indicated genotypes. (E) Plasma CPK concentration (n = 7 MTg mdx, n = 5 non-Tg mdx). (F) Representative H&E-stained quadriceps sections demonstrating histologic improvement of muscle damage in MTg mdx mice (representative of n = 3 per group; *P < 0.05 for indicated comparisons). (Scale bar, 100 µm.) (G) Schematic depicting the role of the GC–KLF15 axis in skeletal muscle. Data are shown as mean ± SEM.