Table 1.
Summary of Putative Entry Inhibitors for Three Viruses from the Prestwick Library.
| Inhibition, % | MARV | AIV | LASV | MARV/AIV | MARV/LASV | AIV/LASV | “Shared” | Nonclassified (MARV/AIV/ LASV) |
|---|---|---|---|---|---|---|---|---|
| >90 | 140 (12)a | 35 (0) | 51 (7) | 28 (0)b | 34 (1) | 25 (1) | 22c | 88/4/7d |
| >80 | 177 (19) | 53 (0) | 84 (10) | 44 (2) | 63 (4) | 37 (1) | 36 | 87/8/10 |
| >70 | 195 (25) | 66 (0) | 115 (14) | 53 (3) | 84 (10) | 46 (1) | 42 | 75/9/13 |
The number of compounds showing >90% inhibition in a screen is listed. Here 140 compounds were identified in the Marburg virus (MARV) screen. However, only 12 compounds, shown in parentheses, were identified as putative entry inhibitors of MARV after comparison with two other virus screens (>90% inhibition in MARV screen but <20% inhibition in the other two screens).
The number of compounds showing >90% inhibition in two screens is listed. Here 28 compounds were identified in the MARV and avian influenza virus (AIV) screens. However, no compound, shown in parentheses, was identified as the putative entry inhibitor for MARV and AIV (>90% inhibition in MARV and AIV screens but <20% inhibition in the Lassa virus [LASV] screen).
The number of compounds showing >90% inhibition in all three screens is listed as “shared.” See text for the explanation.
The number of compounds that cannot be classified as the a, b, or c group in the screens is listed (88 for MARV, 4 for AIV, and 7 for LASV).