Figure 1.

Schematic illustration for the preparation and intracellular activation of siRNA and cisplatin prodrug co-loaded pH-responsive micelleplexes: (a) Pt(IV)-OC was encapsulated in the hydrophobic core and siRNA was loaded on the intermediate layer of the micelleplexes; (b) Intracellular acidic pH-induced activation of micelleplexes. The micelles were dissociated inside acidic late endosome/lysosome due to protonation of the PDPA core. Pt(IV)-OC prodrug and siRNA were then simultaneously released into cytosol due to the strong hemolytic activity of the cationic triblock copolymers.