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. 2016 Jan 1;6(1):14–27. doi: 10.7150/thno.13515

Figure 3.

Figure 3

Intracellular dissociation, serum stability, blood compatibility and siRNA binding affinity of PEG-b-PAGA-b-PDPA micelles with different oligoamine side chain: (a) Fluorescence curves of TMR-labeled PEDA micelles versus pH (the insert shows the fluorescence images of the micelles at different pH values); (b) CLSM images of 4T1 cells treated with TMR-labeled PEDA micelles, Baf-A1 inhibited the intracellular dissociation of PEDA micelles, as indicated by the lack of TMR fluorescence in Baf-A1 pre-treated cells (scale bar = 100 μm); (c) Hemolytic activity of the pH-responsive micelles (**, p < 0.01); (d) Change of hydrodynamic particle size and polydispersity (PDI) versus serum concentrations; (e) siRNA binding ability of PEDA, PDETA, PTETA or PTEPA micelles as determined by gel retardation assay.