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. 2016 Jan 1;6(1):14–27. doi: 10.7150/thno.13515

Figure 4.

Figure 4

Cellular uptake and target gene knockdown of siRNA-loaded pH-responsive micelleplexes: (a) Intracellular distribution of siRNA-FAM loaded PEDA micelleplexes determined by CLSM examination (scale bar = 50 μm); (b) Fluorescence images of A549-GFP cells transfected by siRNA-GFP loaded PEDA micelleplexes or lipoplexes (scale bar = 150 μm); (c) Flow cytometry determined GFP expression in A549-GFP cells transfected with siRNA-GFP loaded PEDA micelleplexes or lipoplexes; (d) Influence of micelle to siRNA weight ratio on GFP knockdown (KD) efficiency of siRNA-GFP loaded micelleplexes; (e) Relative viability of A549-GFP cells after 24 h incubation with siRNA-loaded micelleplexes.