Figure 7.

PEDA micelleplex mediated siRNA-p65 and Pt(IV)-OC prodrug co-delivery significantly inhibited the growth of primary tumor and suppressed lung metastasis: (a) Tumor growth curves in a mouse model bearing 4T1 tumors after treatment with various formulations (the black arrows indicated the injection time points); (b) H&E and (c) tunnel staining of tumor sections; (d-f) Lung metastasis of 4T1 breast tumor determined by (d) photograph, (e) BLI imaging, and (f) H&E staining (the black arrows indicated the location of metastasis nodules in the lung) (200 × for H&E and tunnel staining images). The black arrows in d and f indicate the presence of metastasis nodules in the lungs.