Ravi 2010.
Methods | Parallel‐group randomized trial, conducted in India. Study dates not reported. | |
Participants | 50 people aged 4 ‐ 60 years with ASA physical status I or II undergoing surgery (general, laparoscopic, ENT, paediatric, orthopaedic, obstetric, gynaecological) under general anaesthesia. Exclusion criteria: people with cardiovascular disease, central nervous system problems, previous history of PONV and motion sickness, and smokers. | |
Interventions | Group 1: P6 acupoint injection with 50% 0.2 ml dextrose after induction of anaesthesia (n = 25). Group 2: Ondansetron (50 µg/kg) at end of surgery (n = 25). |
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Outcomes | Nausea (0 ‐6 h), vomiting (0 ‐6 h), rescue antiemetic (ondansetron 4 mg) | |
Notes | Subgroup analysis for adults and children not done as overall population was mixed in age range (4 ‐ 60 years). No details about funding source or any declarations of interest among authors. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Computer‐generated random numbers table. |
Allocation concealment (selection bias) | Unclear risk | Insufficient details given. |
Blinding of patients (performance bias) All outcomes | Low risk | "Both patients and doctors were unaware of the group allocation." |
Blinding of healthcare providers (performance bias) All outcomes | Low risk | "Both patients and doctors were unaware of the group allocation." |
Blinding of outcome assessor (detection bias) All outcomes | Low risk | "An anaesthetist blinded for the study assessed the presence of nausea and vomiting." |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No missing data reported for the 50 participants analysed. |
Selective reporting (reporting bias) | High risk | Incidence of rescue ondansetron 4 mg for intolerable PONV in recovery room and postoperative ward not reported. |
Other bias | Low risk | Age, sex ratio, weight of participants and duration of surgery were similar between groups. |