Lv 2013.

Trial name or title	PC6 acupoint stimulation for prevention of postoperative nausea and vomiting in patients undergoing craniotomy
Methods	Single‐centred, double‐blinded, 5‐arm, parallel‐group RCT
Participants	People undergoing craniotomy
Interventions	Group 1: Ondansetron 8 mg IV before skin closure and PC6 acupuncture bilaterally for 30 min after regaining consciousness from general anaesthesia with stimulation every 10 min to keep de qi sensation. Group 2: Ondansetron 8 mg IV before skin closure and sham PC6 acupuncture bilaterally for 30 min after regaining consciousness from general anaesthesia with no stimulation. Group 3: Ondansetron 8 mg IV before skin closure and PC6 stimulation via active TENS electrodes bilaterally for 30 min after regaining consciousness from general anaesthesia with stimulation intensity and frequency set to when de qi sensation is felt. Group 4: Ondansetron 8 mg IV before skin closure and PC6 stimulation via inactive TENS electrodes bilaterally for 30 min after regaining consciousness from general anaesthesia with no stimulation intensity and frequency. Group 5: Ondansetron 8 mg IV before skin closure.
Outcomes	Nausea (0 ‐ 24 h), vomiting (0 ‐ 24 h), rescue antiemetic (metoclopramide)
Starting date	January 2013
Contact information	zhenjiuhuaxi@163.com.
Notes	Protocol published in Trials 2013 May 28;14:153. doi: 10.1186/1745‐6215‐14‐153. This study is registered with the Chinese Clinical Trial Registry: ChiCTR‐TRC‐13003026.

h = hours
 ICU = Intensive care unit
 IV = intravenous
 PC6 = pericardium acupoint
 RCT = randomized controlled trial
 TENS = transcutaneous electrical nerve stimulation