Table 1.

MicroRNA biomarkers in blood for gastric cancer.

ID	Sample	Features	Poor Survival	Expression	Reference	Validated Targets
miR-122	96 GC 7 BGC 10 CG 36 HC	Distance metastases	Down	Down	Chen et al.[68]	-
miR-17-5p	79 PRE GC 30 POST GC 6 relapse GC	Differentiation TNM stages	Up	Up1	Wang et al.[30]	-
miR-18a	82 GC 65 HC	LNM Pathological grade	Up*	Up	Su et al. [66]	-
miR-20a	79 PRE GC 30 POST GC 6 relapse GC	Differentiation TNM stages	Up	Up1	Wang et al.[30]	-
miR-200c	67 GC 15 HC	LNM	Up	Up	Valladares-Ayerbes et al.[64]	BCL2, XIAP[99]
miR-203	154 GC 22 HC	Gender Lymphatic invasion Venous invasion Peritoneal metastasis Distance metastasis LNM Liver metastasis TNM stage	Down	Down	Imaoka et al. [28]	-
miR-21	69 GC	Venous invasion	Up*	-	Komatsu et al.[26]	RECK[92] PTEN[100] Serpini1[101]
miR-21	42 PRE GC 42 POST GC	Differentiation LNM	-	Up1	Ma et al.[27]	RECK[92] PTEN[100] Serpini1[101]
miR-218	68 GC 56 HC	Metastasis Tumor stage	Down	Down	Xin et al.[69]	ECOP[102]
miR-221	82 GC 46 dysplasia 128 SG or CAG	Differentiation	-	Up	Song et al.[31]	p27, p57 [103] PTEN[104]
miR-222	114 GC 36 CAG 56 HC	LNM	Up	Up	Fu et al.[65]	p27, p57 [103] PTEN[104] RECK[105]
miR-25	Tissue: 33 GC 33 HC Blood: 70 GC 70 HC	LNM TNM stage	Up	Up	Li et al.[70]	p57 [103] BCL2L11[106] FBXW7[46]
miR-27a	82 GC	Metastasis Recurrent	Up	Up	Huang et al.[67]	Prohibitin [107] APC[108]
miR-376c	82 GC 46 dysplasia 128 SG or CAG	Differentiation	-	Up	Song et al.[31]	-
miR-744	82 GC 46 dysplasia 128 SG or CAG	Differentiation	-	Up	Song et al.[31]	-

Abbreviations and note: BGC: benign gastric ulcer; CAG: chronic atrophic gastritis; CG: chronic gastritis; GC: Gastric cancer; HC: healthy control; LNM: Lymph node metastasis; PRE: pre-operative; POST: post-operative; SG: superficial gastritis; ^* Disease-specific; ¹ Pre-operation.