Table 2.

MicroRNA biomarkers in tissues for gastric cancer.

ID	Sample	Features	Poor Survival	Expression	Reference	Validated Targets
miR-107	161 GC 161 ANTT	Invasion LNM Tumor stage	Up	Up	Inoue et al. [41]	CDK6[40] DICER1[41]
miR-1207-5p	23 GC with LNM 23 GC without LNM	LNM Lymphovascular invasion Stromal reaction type TNM stage	-	Down1	Huang et al. [53]	-
miR-125a-3p	70 GC 70 ANTT	Invasion LNM Liver metastasis Tumor stage Tumor size Peritoneal dissemination	Down	Down	Hashiguchi et al. [48]	-
miR-125a-5p	87 GC	Invasion depth Liver metastasis Tumor stage Tumor size	Down	Down4	Nishida et al. [47]	ERBB2[47]
miR-130a	41 GC 41 ANTT	Metastasis Invasion Proliferation	Up	Up	Jiang et al. [45]	RUNX3[45]
miR-141	36 GC 36 ANTT	Invasion Proliferation Metastasis	-	Down	Zuo et al. [54]	-
miR-142-5p	29 REGC 36 non-REGC	Recurrence	Up	Down2	Zhang et al. [76]	-
miR-143	138 GC 30 NTT	Tumor stage Scirrhous type	Up*	Up	Naito et al. [73]	-
miR-145	138 GC 30 NTT	Tumor stage Scirrhous type	Up*	Up	Naito et al. [74]	CDH2[109]
miR-148a	106 GC 106 ANTT	Distant metastasis Organ invasion Peritoneal invasion	Down	Down	Tseng et al. [50]	DNMT1[110] p27[111] ROCK1 [63]
miR-153	80 GC 80 ANTT	Invasion LNM Migration	Down	Down	Zhang et al [55]	-
miR-181c	103 GC	Differentiation Invasive depth Tumor stage	Up	Up4	Cui et al. [32]	NOTCH4, KRAS[112] BCL2[113]
miR-192	118 GC 118 ANTT	Tumor sizes Borrmann type	-	Down3	Chiang et al [61]	-
miR-192	38 GC 38 ANTT	LNM	-	Up	Xu et al. [62]	-
miR-193b	48 GC 48 ANTT	Differentiation Lauren type Tumor stage Invasion Metastasis	Down	Down	Mu et al. [35]	-
miR-195	45 GC	Recurrence	-	Up2	Brenner et al. [75]	-
miR-196a	109 GC 20 ANTT	Invasion depth Serosal invasion Lymphatic invasion LNM Distant metastasis TNM stage Peritoneal seeding Gross type Lauren subtype	Up	Up	Tsai et al. [44]	radixin[44]
miR-196a	48 GC 48 ANTT	Differentiation	Up	Up	Mu et al. [35]	-
miR-196a-5p	58 GC 58 ANTT	LNM TNM stage	Up	Up	Li et al. [58]	-
miR-199a-3p	45 GC	Recurrence	-	Up2	Brenner et al. [75]	SMARCA2 [114]
miR-199a-5p	28 GC 48 GC LNM 25 NTT	Metastasis	-	Up	Zhao et al. [60]	MAP3K11 [115] Smad4[116] SMARCA2 [114]
miR-196b	109 GC 20 ANTT	Invasion depth Serosal invasion Lymphatic invasion LNM Distant metastasis TNM stage Peritoneal seeding Gross type	Up	Up	Tsai et al. [44]	-
miR-206	98 GC 98 ANTT	Venous invasion LNM Hematogenous recurrence pStage	Down	Down	Yang et al. [51]	CCND2[117]
miR-20b	102 GC 102 ANTT	LNM Distance metastasis TNM stage	Up	Up	Xue et al. [59]	-
miR-21	56 GC without LNM 30 GC with LNM 72 ANTT	Differentiation LNM	Up	Up	Xu et al. [33]	RECK[92] PTEN[100] Serpini1[101]
miR-215	118 GC 118 ANTT	Borrmann type Tumor sizes pT stage	-	Down3	Chiang et al [61]	-
miR-215	38 GC 38 ANTT	-	-	Up	Xu et al. [62]	-
miR-217	83 GC 83 ANTT	Differentiation Distant metastasis Invasion Tumor size TNM stag	Down	Down	Chen et al. [36]	-
miR-22	98 GC 98 ANTT	LNM Distant metastasis pStage	Down	Down	Yang et al. [51]	SP1[118]
miR-23a/b	160 GC 160 ANTT	Invasion LNM TNM stage	Up	Up	Ma et al. [43]	IL6R[119]
miR-25	40 GC 40ANTT	Invasion Proliferation LNM Migration	Up	Up	Gong et al [46]	p57 [103] BCL2L11[106] FBXW7[46]
miR-29c	115 GC 115 ANTT	Venous invasion TNM stage	-	Down	Gong et al. [52]	-
miR-335	31 REGC 43 non-REGC	Recurrence	Up	Up2	Yan et al. [77]	-
miR-34a	137 GC 137	Lymph node involvement TNM stage Differentiation Tumor recurrence	Down	Down	Zhang et al. [34]	BCL2[120]
miR-375	29 REGC 36 non-REGC	Recurrence	Up	Up2	Zhang et al. [76]	PDK1, YWHAZ[121] JAK2[122]
miR-451	45 GC	Recurrence	Up*	Up2	Brenner et al. [75]	MIF [123]
miR-520d-3p	120 GC 120 ANTT	Invasion depth LNM Tumor stage	Down	Down	Li et al. [49]	-
miR-630	236 GC 236 ANTT	Invasion LNM Distant metastasis TNM stage.	Up	Up	Chu et al. [42]	-
miR-92a	97 GC	Tumor growth	Up	-	Wu et al. [78]	-

ANTT: adjacent non-tumor tissues; GC: gastric cancer; LNM: Lymph node metastasis; NTT: non-tumor tissues; REGC: gastric cancer with recurrence; non-REGC: GC without recurrence;

^* Disease-specific; ¹ LNM samples; ² Recurrence; ³ GC cell line; ⁴ advanced GC