Table 3.

Top 10 significantly enriched pathways by targets of microRNA biomarker from GC blood and tissue.

Source	Ingenuity Canonical Pathways	p-value	Ratio	miRNA
Blood	Molecular Mechanisms of Cancer	1.00E-11	0.39	miR-200c, miR-21, miR-25
	Glucocorticoid Receptor Signaling	6.76E-09	0.37	miR-200c, miR-21, miR-25
	IGF-1 Signaling	2.95E-08	0.48	miR-200c, miR-21, miR-221
	Wnt/β-catenin Signaling	6.46E-08	0.43	miR-25, miR-21, miR-200c
	Pancreatic Adenocarcinoma Signaling	1.12E-07	0.48	miR-21, miR-200c, miR-20a
	AMPK Signaling	1.35E-07	0.40	miR-200c, miR-21, miR-25
	p53 Signaling	2.82E-07	0.46	miR-21, miR-200c, miR-20a
	14-3-3-mediated Signaling	3.09E-07	0.44	miR-200c, miR-221, miR-21
	Chronic Myeloid Leukemia Signaling	5.13E-07	0.46	miR-20a, miR-200c, miR-21
	Myc Mediated Apoptosis Signaling	5.50E-07	0.56	miR-20a, miR-200c, miR-21
Tissue	Molecular Mechanisms of Cancer	3.98E-16	0.59	miR-21, miR-25, miR-23b
	Germ Cell-Sertoli Cell Junction Signaling	7.94E-14	0.69	miR-141, miR-23b, miR-21
	PI3K/AKT Signaling	2.51E-11	0.70	miR-22, miR-23b, miR-195
	Epithelial Adherens Junction Signaling	7.94E-11	0.65	miR-23b, miR-21, miR-141
	p53 Signaling	3.89E-10	0.70	miR-23b, miR-21, miR-141
	Mouse Embryonic Stem Cell Pluripotency	4.17E-10	0.73	miR-143, miR-451a, miR-21
	HGF Signaling	8.32E-10	0.68	miR-21, miR-23b, miR-196b
	Wnt/β-catenin Signaling	2.14E-09	0.61	miR-141, miR-25, miR-34a
	Chronic Myeloid Leukemia Signaling	2.29E-09	0.69	miR-21, miR-34a, miR-22
	Regulation of the Epithelial-Mesenchymal Transition Pathway	2.88E-09	0.62	miR-141, miR-21, miR-22

The overlapped pathways are marked by underline. The ratio is the percentage of the mapped genes divided by the number of total genes in the pathway.