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Outcomes for the subgroup of patients with CNS metastases at baseline. (A) Progression-free survival according to independent review committee, (B) progression-free survival according to investigator assessment, (C) time-to-symptom progression and (D) overall survival. CI, confidence interval; CNS, central nervous system; HR, hazard ratio; T-DM1, trastuzumab emtansine; XL, capecitabine – lapatinib.
