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. 2015 Nov 30;2(4):282–298. doi: 10.3390/jcdd2040282

Figure 5.

Figure 5

A schematic illustration summarizing the fate decision of cells in the developing venous pole. In the early developing venous pole, Shox2 is expressed in the SAN head domain as well as the myocardium of the LSVC and RSVC, which are all positive for Hcn4. In addition, the SAN tail/peripheral domain and the PV myocardium are positive for Shox2, Nkx2-5, and Hcn4. At the late developmental stage and adult, the myocardium of the PV, LSVC, and RSVC becomes matured and largely adopts working myocardial phenotype, with potential to reacquire pacemaking activities.