TABLE 2.
Amniotic fluid cytokines and prostaglandins
| Preinflation |
Postinflation |
P value |
||||
|---|---|---|---|---|---|---|
| Analyte | Saline infusion (N = 5) | Balloon inflation (N = 6) | Saline infusion | Balloon inflation, no labor (N = 2)a | Balloon inflation, labor (N = 3) | Saline vs balloon, labor |
| IL-1β | 0.003 (0.001) | 0.03 (0.02) | 0.005 (0.002) | 1.3 (1.1) | 3.7 (3.3) | .003 |
| TNF-α | 0.01 (0.009) | 0.02 (0.008) | 0.02 (0.01) | 0.4 (0.3) | 0.9 (0.4) | .02 |
| IL-6 | 4.3 (1.4) | 8.4 (3.7) | 10.7 (2.2) | 28.4 (21.2) | 78.3 (25.9) | .02 |
| IL-8 | 0.8 (0.2) | 8.9 (3.8) | 1.5 (0.3) | 13.6 (10.2) | 26.9 (2.4) | .001 |
| CCL2 | 1.4 (1.0) | 1.9 (0.9) | 3.0 (2.0) | 5.3 (3.8) | 9.4 (3.5) | .007 |
| PGE2 | 0.7 (0.6) | 0.09 (0.02) | 0.7 (0.5) | 0.4 (0.3) | 1.3 (0.4) | .001 |
| PGF2α | 0.3 (0.06) | 0.3 (0.09) | 0.7 (0.1) | 0.7 (0.2) | 2.9 (1.2) | <.001 |
Table presents mean (SEM). Values for amniotic fluid analyses are ng/mL. P values are based on analysis of covariance models adjusting for baseline. Saline infusion was performed in both amniotic fluid and choriodecidual compartments. Balloon inflation was performed within amniotic cavity.
CCL, chemokine (C-C motif) ligand; IL, interleukin; PGE2, prostaglandin E2; PGF2α, prostaglandin F2α; TNF, tumor necrosis factor.
a
No amniotic fluid could be obtained from 1 animal undergoing balloon inflation with no labor, reducing N to 2 in this group.