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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Bone. 2015 Jul 23;82:101–107. doi: 10.1016/j.bone.2015.07.025

Figure 3. CYP27B1 and SLC34A1 gene expression.

Figure 3

Differences (mean ± SD) in renal gene expression (fold-change vs. CONT+VEHICLE) for (A) CYP27B1 and (B) SLC34A1 genes are shown. The product of the CYP27B1 gene, 25-hydroxyvitamin D-1α-hydroxylase, functions to synthesize 1, 25-(OH)2 vitamin D3 from 25-(OH) vitamin D3; CYP27B1 gene expression is upregulated in response to PTH and to hypocalcemia. The SLC34A1 gene encodes for the renal sodium-phosphate co-transporter, responsible for phosphate reabsorption in the proximal tubule. Co-transporter function is reduced by PTH, contributing to phosphaturia. Statistically significant between-group differences (and p-values) are delineated, showing a significant increase in CYP27B1 and decrease in SLC34A1 in diabetic mice (STZ+VEHICLE), which is in keeping with the increase in mean serum PTH observed in diabetic mice (Figure 2A).