. Author manuscript; available in PMC: 2017 Jan 1.

Published in final edited form as: Inflamm Bowel Dis. 2016 Jan;22(1):224–233. doi: 10.1097/MIB.0000000000000589

Table 6.

Cumulative MTX dose and histologic evaluated liver toxicity.

Study	Number of patients	Mean cumulative dose MTX (mg)	Range cumulative dose MTX (mg)	Histological evaluation¹¹⁰
Study	Number of patients	Mean cumulative dose MTX (mg)	Range cumulative dose MTX (mg)	Early changes (Roenigk I, II)	Advanced changes Roenigk III, IV)
Te 2000¹¹¹	20	2,633	1,500 – 5,140	19	1
Leman 2000⁴⁸	11	1,225^*	220 – 3,400^*	9	2
Fraser 2002¹¹²	3	>1,500	not reported	3	0
Fournier 2010⁷⁸	17	2,653	1,400 – 6,025	16	1
Laharie 2006 and 2010^{102, 104}	7	3,152	2,170 – 5,705	5	2

Mean MTX dose and MTX dose range of 41 patients, of whom 11 underwent liver biopsy